Update on Janus Kinase Antagonists in Inflammatory Bowel Disease
نویسندگان
چکیده
منابع مشابه
The Future of Janus Kinase Inhibitors in Inflammatory Bowel Disease
Inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease, are disabling conditions characterised by chronic, relapsing inflammation of the gastrointestinal tract. Current treatments are not universally effective or, in the case of therapeutic antibodies, are hampered by immune responses. Janus kinase inhibitors are orally delivered small molecules that target cytokine signall...
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This PDF was generated from an article on http://drhoffman.com/ © 2017 Ronald L. Hoffman MD, PC. All Rights Reserved | 1 Ulcerative colitis and Crohn’s disease are two conditions that have many features in common and are sometimes referred to as “inflammatory bowel disease” (IBD). While not as common as less severe conditions like “irritable bowel syndrome,” Crohn’s disease and ulcerative colit...
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Women with inflammatory bowel disease have similar rates of conception to the general population unless they have had pelvic surgery. Once pregnant, regardless of disease activity, they have an increased risk of adverse pregnancy outcome and should be followed as high-risk obstetric patients. Most medications are compatible with pregnancy and lactation, as described in this article. Ideally, wo...
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Although tumor necrosis factor (TNF)-α antagonists play a critical role in the treatment of moderate-to-severe inflammatory bowel disease (IBD), several factors can impact treatment response. The degree of systemic inflammation, serum albumin concentration, disease type, body mass index, gender, concomitant therapy with immunosuppressive agents, and especially development of antidrug antibodies...
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Very-early-onset inflammatory bowel disease (VEO-IBD) has a distinct phenotype and should be considered a specific entity. VEO-IBD presents with very severe clinical pictures and is frequently known by an indeterminate colitis whose clinical remission is unmanageable. This study examines the case of a neonate with VEO-IBD, not responding to medical and surgical treatment. A 7-day-old Iranian fe...
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ژورنال
عنوان ژورنال: Gastroenterology Clinics of North America
سال: 2014
ISSN: 0889-8553
DOI: 10.1016/j.gtc.2014.05.011